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  • Writer's pictureMackenzie Chen

Psoralen: The Silent Killer

Psoralea corylifolia or babchi was an herb historically used to magically cure several skin

diseases, commonly found in traditional Ayurvedic and Chinese medicine. Ironically, it has since

been discovered that it produces psoralen, which is a type of furanocoumarin. A chemical

generally derived from plants, furanocoumarins can induce phototoxic reactions in humans.


When a person has direct contact with a plant that produces psoralen, their epidermal or skin

cells will take up the chemical and intercalate it into DNA via the minor and major grooves. This

becomes extremely problematic when a person then has exposure to ultraviolet light because

that light will cause DNA to form covalent rather than hydrogen bonds. With these covalent

cross links, it becomes harder for DNA to replicate because they cannot separate as easily

anymore. This complication with replication results in skin cell injury as damaged cells can no

longer be replaced and ultimately cell death.


Despite the safety concerns associated with psoralen, it was actually still used as an oral or

topical ointment to treat psoriasis, vitiligo, and even cutaneous T cell lymphoma. In the 1950s,

8-methoxsalen, a common form of psoralen, was used in combination with ultraviolet light

treatment (PUVA) to treat the most severe psoriasis, a condition where scaly patches of skin

form due to an overactive immune system.


Some of the known side effects of using psoralen include nausea, headaches,

dizziness, fatigue, and depression. Some particularly extreme but rare effects consist of an

increased risk of developing basal cell carcinoma and melanoma. Furthermore, in other case

studies, more incidents of acute liver injury have been correlated to an increased use of

powders and teas prepared from Psoralea corylifolia, a key ingredient in many Chinese

medications.


Currently, psoralen is not typically used to treat skin conditions out of concerns over the safety

of ultraviolet light therapy and the availability of newer drugs to care for psoriasis. Overall, it is

very clear that your skin is often at the mercy of the unpredictable qualities of wildlife. One plant

can rob the ability of epidermal cells to replicate after being damaged, leading to an overall

reduction in skin cells over time. Amazingly, the mere act of brushing against a plant can alter skin cells at the most fundamental level.


Mackenzie Chen is a 2nd Year student at the University of Virginia. Edited by Isaac Yoo.


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